Document 3101
 DOCN  M94A3101
 TI    Mortality patterns in a hemophilia cohort followed for 14 years.
 DT    9412
 AU    Karafoulidou A; Touloumi G; Louizou C; Markakis C; Economidou I;
       Hatzakis A; Mandalaki T; Laikon Hospital, Athens, Greece.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):153 (abstract no. PB0039). Unique
       Identifier : AIDSLINE ICA10/94369474
 AB    OBJECTIVE: To describe the long term mortality patterns in a hemophilia
       cohort. METHODS: 158 hemophiliacs (149 hemophilia A, 4 hemophilia B and
       5 Von Willebrand's disease) seroconverted to HIV between 1980 and 1985.
       The presumed date of seroconversion was calculated by smooth models
       based on spline functions (Kroner and Rosenberg, 1993, submitted). The
       mean (SD) age at time of seroconversion was 26.2 (15.4), range 1.3-86.0
       years. The mean (SD) duration of follow up time from seroconversion was
       9.1 (2.4), median 9.8, range 1.1-12.7 years. RESULTS: By November 1993
       40 patients had developed AIDS and 55 died. 31 patients died from causes
       directly attributed to HIV and AIDS and 24 died from other causes. The
       Kaplan Meier estimation of progression risks are shown. TABULAR DATA,
       SEE ABSTRACT VOLUME. The risk of death was highly depended on age at
       seroconversion (p = 0.000). Survival after diagnosis of AIDS was not
       associated with age at time of AIDS. The distribution of various causes
       of death among AIDS cases did not change during the follow up period
       despite the substantial improvement of survival after AIDS diagnosis
       which was observed after antiretroviral and PCP prophylaxis treatment (p
       = 0.004). DISCUSSION AND CONCLUSIONS: The progression rate to AIDS
       remains relatively slow in this hemophilia cohort. However, there is a
       substantial burden of fatal diseases not formally related to AIDS.
 DE    Acquired Immunodeficiency Syndrome/*MORTALITY/TRANSMISSION  Adolescence
       Adult  Age Factors  Aged  Aged, 80 and over  Child  Child, Preschool
       Cohort Studies  Comparative Study  Follow-Up Studies
       Hemophilia/*MORTALITY  Human  HIV Seropositivity/MORTALITY  Infant
       Middle Age  Risk Factors  Survival Analysis  Time Factors  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).